【Active ingredient】
Single-stranded RNA fragment in HVJ-E particles:
Induces cancer cell death and release/recognition of cancer antigens
Activation of many kinds of immune cells
Expand indications for various diseases by changing the types of nucleic acid medicines such as siRNA and mRNA
【Effect】
HVJ-E-derived RNA fragments and F protein induce cancer cell-specific killer T cells and NK cells via activation of dendritic cells, as well as shift of macrophages and neutrophils in tumor tissues from tumor-promotion to tumor suppression types (M1 and N1 types)